Vitamin D is essential for the activation of many genes that play important roles in health. Vitamin D deficiency has been linked to heart disease, type 2 diabetes, autoimmune disorders, and Alzheimer's disease. Vitamin D may increase longevity and lower the risk of several aging-related disorders. May also have some side effects, such as gastrointestinal discomfort or a rare but serious condition called lactic acidosis, particularly in people with kidney problems, although metformin is generally safe and well-tolerated.ĭosage: ideally 4,000 to 5,000 IU per day. May have some potential benefits for cardiovascular health, including reducing the risk of heart disease. May have some benefits for cancer prevention and treatment, although more research is needed to fully understand its effects in this area. Has been shown to improve insulin sensitivity and lower blood glucose levels, which can help prevent or manage type 2 diabetes. May have anti-aging effects and could potentially increase lifespan. What did David Sinclair say about metformin?Īccording to the interviews, lectures, and book “Lifespan: Why We Age and Why We Don't Have To” of Dr. However, research shows that metformin may reduce the benefits of exercise so he skips metformin during the days of his workouts. David Sinclair’s metformin consumption provides benefits of improving his insulin sensitivity and keeping a well-regulated blood glucose level.

Metformin may also cause diarrhea and gastrointestinal pain temporarily, but this usually passes after a few weeks.ĭr. However, since metformin is a prescription medication, one must first consult with a doctor. People with diabetes under metformin treatment lived longer than those who are not. There are pieces of evidence showing that a drug against type 2 diabetes (T2D) called metformin increases lifespan in a variety of animal models, including mammals. Subscribe and save 10% on your Purovitalis orders! On the other hand, in a study of older women’s insulin sensitivity, 250 to 500 mg is also adequate. Some companies even developed special liposomal NMN formulations to protect it and ensure maximal absorption even with lower doses. It may be a lot, but this dosage may be reasonable since NMN can be destroyed by stomach acid. David Sinclair’s NMN supplement intake involves high-dose supplementation (1,000 mg) to boost his NAD+. Notably, boosting NAD+ levels via NMN intake can delay and even reverse certain aspects of aging.ĭr. NAD+ levels lower as we age and can cause dysfunctions that lead to aging and disease development. NMN boosts the production of NAD+, a crucial molecule that fuels a lot of our cellular metabolic reactions needed for survival. Supplement/Drugĥ00 mg each, once per day, in the morning Sinclair's longevity and drug stack that was derived from his interviews and books in which he discussed the supplements that he consumes. David Sinclair take? What is his anti-aging secret? Here, we list Dr.

Many people have been asking: what supplements does Dr. True to form, his biological or epigenetic age turns out to be much younger than his chronological age. Sinclair believes living up to 150 years or even longer is possible, and he found ways to delay aging.

His peers this age may already have gray to white hairs, complain of lower back pain, or been afflicted with health disorders, but not him.Īs a world-renowned scientific leader in the field of aging and longevity, Dr. David Sinclair certainly does not seem his age.

Benefits of supplement stacks